What is a mature adult supposed to be?
1. Sincerely consider your career path, forget the Supertramp idea.
2. Be practical. Understand you belongs to the society and stop blaming the society force you to do things. Play the rules.
3. Think of your parents. (why I still let them worry about me?)
4. Be grateful. (Do you understand how much you own?)
I guess I am still far away to this state of mind.
Wednesday, October 6, 2010
Monday, October 4, 2010
Decision-making process
"I would like to support you and provide you a better life after I graduated. So it's ok we separated for several years. This separation is for our better future."
How naive I was.
[You have to be competitive. Find a big boss as your postdoc advisor. Move to some places which have better opportunity ]
"I just want to break the cycle that I am forced to do things. I want to have a job and stay with him at the same place."
[No, it's not the time. You have to fight for your career as a computational chemist. ]
How naive I am.
Nothing changes after five years.
How naive I was.
[You have to be competitive. Find a big boss as your postdoc advisor. Move to some places which have better opportunity ]
"I just want to break the cycle that I am forced to do things. I want to have a job and stay with him at the same place."
[No, it's not the time. You have to fight for your career as a computational chemist. ]
How naive I am.
Nothing changes after five years.
Friday, October 1, 2010
The small clashes between the medicinal chemist and the computational chemist
Recently I took over a small project (or service ) from my friend, a blooming synthetic medicinal chemist.
After her advisor's seminar for his 10n-year amazing service ( [repetitively organic synthesis on certain Chinese medicinal compounds with known cytotoxicity]*20 projects ), I feel how trivial a computational chemist contribute in the drug discovery field compared to hands-on medicinal chemists.
So the story of the manuscript is ...
She wants to demonstrate some fragments (Mol. Weight < 250-300) which have some cytotoxicity are tyrosine kinase inhibitors (e.g., c-Src is a famous anticancer target). The reason they suspect those fragments are kinase inhibitors based on a common two-ring system.
[clash1: the degree of similarity is based on certain metric calculated by certain descriptors @@]
Then I suggested her to use the compounds as probes to see if she can find some kinase compounds in database. hmmm... one scaffold was found.
Since our lab doesn't develop any software related to in silico target identification, we tried the online target fishing server.
Eventually, I decided to dock the compounds against one cancer target. (shouldn't I do this at the beginning?) Everyone is happy at the pretty docking picture but I understand most of them are just pretty.
Again, I feel so useless at least they have some compounds with certain amount cytotoxicity against unknown targets. I have many results to show there is low probability of those compounds against kinase.
Conclusion: be positive despite the low probability
After her advisor's seminar for his 10n-year amazing service ( [repetitively organic synthesis on certain Chinese medicinal compounds with known cytotoxicity]*20 projects ), I feel how trivial a computational chemist contribute in the drug discovery field compared to hands-on medicinal chemists.
So the story of the manuscript is ...
She wants to demonstrate some fragments (Mol. Weight < 250-300) which have some cytotoxicity are tyrosine kinase inhibitors (e.g., c-Src is a famous anticancer target). The reason they suspect those fragments are kinase inhibitors based on a common two-ring system.
[clash1: the degree of similarity is based on certain metric calculated by certain descriptors @@]
Then I suggested her to use the compounds as probes to see if she can find some kinase compounds in database. hmmm... one scaffold was found.
Since our lab doesn't develop any software related to in silico target identification, we tried the online target fishing server.
Eventually, I decided to dock the compounds against one cancer target. (shouldn't I do this at the beginning?) Everyone is happy at the pretty docking picture but I understand most of them are just pretty.
Again, I feel so useless at least they have some compounds with certain amount cytotoxicity against unknown targets. I have many results to show there is low probability of those compounds against kinase.
Conclusion: be positive despite the low probability
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